Job Description

Job Description

We are on a quest for cures and are committed to be the world's premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.

We are seeking an exceptional and experienced scientist in the role of Principal Scientist of Discovery Protein Analytics in the Boston Discovery Biologics group.- The Principal Scientist will be responsible for the leading of a team of discovery scientists focused on advanced analytical characterization of protein therapeutics including mass spectrometry (intact, peptide mapping for glycoform and other post-translational modification analyses), liquid chromatography including SEC and HIC, CE-SDS, cIEF, thermal stability techniques, and other analytical approaches to advance discovery programs from hit-to-lead-to-candidate, and they should have demonstrated experience applying fit-for-purpose, high-throughput analytical characterization techniques in the early drug discovery setting. The scientific leader will be responsible for continued expansion of early developability workflows in Boston in collaboration with the broader Discovery Biologics organization and with downstream organizations at our company.-

In collaboration with project teams and as a member of department working groups, they will drive the advancement of hits and leads through the biologics pipeline. The role is a key interface within the Boston group and the global Discovery Biologics network, as well as with our process development colleagues at the interface of protein therapeutics discovery and development and other drug discovery functions within our company, as well as with external academic and industrial partners.

As a people manager, they will invest in the growth and development of current and future staff to create a culture of collaboration and accountability to enable shared success. The leader will work closely with their team members to leverage strengths and identify opportunities to continually expand skillsets, leadership, and enterprise thinking. -We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees.- Successful candidates must demonstrate inclusive behaviors in working with a diverse group of researchers to drive our core mission.

What you will do:

• Provide scientific leadership to a team of scientists focused on analytical characterization of a wide variety of protein therapeutic molecules to identify strong candidate molecules for development
  
• Drive optimization and expansion of protein analytics capabilities and workflows, including advancement of automated solutions for characterization workflows for mass spectrometry, chromatography, and other biophysical characterization methods
  
• Execute on early developability workflows to advance complex protein therapeutics beyond traditional mAbs, including alternative non-Ig scaffolds, bi- or multispecifics, fusion proteins, and ADCs, to quickly identify the most promising lead molecules
  
• Manage priorities, resources, and investments aligned with the Discovery Biologics strategy
  
• Lead and participate in cross-functional project teams to deliver impactful protein therapeutics from discovery to development
  
• Foster a high-performance culture of collaboration, engagement, self-accountability and inclusion
  
• Stay abreast of external advancements in relevant scientific fields
  
• Promote the external reputation of our company's Discovery Biologics department
  

What you will need to be successful in this role:

Qualifications & Experience

• PhD life sciences or related field with 8+ years of applied experience in a biopharmaceutical setting, MS and 10+ years of experience, or BS and 14+ years of experience
  
• Experience in protein analytical characterization in the early drug discovery setting (prior to candidate selection)
  

Required skills:

• Deep scientific knowledge of the workflows required for the discovery and analysis of protein therapeutics
  
• Strong technical knowledge of in-depth analytical characterization techniques for biologics, including mass spectrometry (intact, peptide mapping for glycoform and other post-translational modification analyses), SEC, HIC, RP, CE-SDS, cIEF, thermal stability
  
• Significant project team experience for programs across drug discovery stages, from tool-molecule generation through preclinical development of therapeutic candidates
  
• Prior direct people management of 2+ FTEs, with demonstrated experience in career development
  
• Champion for diverse and inclusive culture
  

Preferred skills:

• Strong presentation and publication record
  
• Experience executing early developability assessments of protein therapeutics
  
• Ideal candidate will have experience in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds, bi- or multispecifics, fusion proteins, and ADCs
  
• Prior program leadership experience
  
• Prior experience working at the discovery-development interface to facilitate the transition of preclinical candidate molecules into downstream process development-related functions and activities
  
• Experience in lab automation, including automated analytical data acquisition and analysis workflows
  
• Experience in outsourcing and managing external collaborations
  

Your role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At our company, we're inventing for life.

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. - All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. - For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
Not Applicable

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
OEB4, harsh chemicals, highly potent proteins

Job Posting End Date:
11/8/2024
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R315445

Job Tags

Full time, Local area, Remote job, Relocation, Visa sponsorship, Flexible hours, Shift work, 3 days per week,

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